Cognitive
Semax
ACTH(4-7)–Pro–Gly–Pro (Heptapeptide)
Evidence tier: Human clinical use in Russia (stroke, cognitive decline, ADHD). Limited Western RCT data.
| Molecular weight | 813.9 Da |
| Molecular formula | C37H51N9O10S |
| CAS number | 80714-61-0 |
| Half-life | ~20 minutes (plasma); effects last several hours |
| Administration | intranasal |
| Research dose | 200–900 µg/day intranasal, split into 1–2 doses |
Amino Acid Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Primary Mechanism
BDNF and NGF upregulation, dopaminergic modulation, ACTH receptor agonism
Studied For
cognitive enhancementneuroprotectionstroke recoveryADHDstress resilience
Reconstitution
Typically supplied as a pre-made nasal solution (0.1% or 1%). Store refrigerated.
Storage
Refrigerate at 2–8°C. Do not freeze the nasal solution. Stable for several months refrigerated.
Notes
Registered medicine in Russia. Approved for clinical use for stroke and brain injury. Better human evidence base than most nootropic peptides.
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