Cognitive
PE-22-28
PE-22-28 (Spadin Analog)
Evidence tier: Animal studies only. Very early-stage research.
| Molecular weight | 882.9 Da |
| Molecular formula | C31H54N14O14 |
| Half-life | Unknown |
| Administration | subcutaneous, intranasal |
| Research dose | Not established in humans. Animal studies use mg/kg ranges. |
Amino Acid Sequence
Ser-Arg-Arg-His-Thr-Ser-Glu
Primary Mechanism
TREK-1 potassium channel blockade, rapid synaptic BDNF release, neurogenesis
Studied For
depression (animal)neurogenesisrapid antidepressant effectBDNF upregulation
Reconstitution
Reconstitute with bacteriostatic water.
Storage
Lyophilised: store at -20°C. Reconstituted: refrigerate, use within 30 days.
Notes
Synthetic analog of spadin, itself a fragment of the prosaposin propeptide. TREK-1 channel blockade is a novel antidepressant mechanism distinct from SSRIs. Very new — minimal published data. Approach with appropriate caution.
This page contains affiliate links. If you purchase through these links, I may earn a commission at no extra cost to you.
These products are sold for research purposes only and are not intended for human consumption.