← Peptide Index
Longevity

MOTS-c

Mitochondrial Open Reading Frame of the 12S rRNA-c

Evidence tier: Animal studies. Emerging human observational data (circulating levels correlate with metabolic health).
Molecular weight2174.6 Da
Molecular formulaC95H152N30O27S
CAS number1627580-76-0
Half-lifeUnknown
Administrationsubcutaneous, intramuscular
Research dose5–10 mg per week (animal-extrapolated; no established human dose)

Amino Acid Sequence

MRWQEMGYIFYPRKLR

Primary Mechanism

AMPK activation, mitochondrial biogenesis, insulin sensitisation, exercise-mimetic signalling

Studied For

metabolic healthinsulin sensitivityobesityexercise performancelongevity

Reconstitution

Reconstitute with bacteriostatic water. For a 5 mg vial add 1 mL BW for a 5,000 µg/mL solution.

Storage

Lyophilised: store at -20°C. Reconstituted: refrigerate at 2–8°C, use within 30 days.

Notes

Mitochondrially encoded peptide — one of very few. Circulating levels decline with age. Activates AMPK similarly to exercise and metformin. Cohen lab (USC) primary researchers.

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