Longevity
Humanin
Humanin (24-amino acid mitochondrial peptide)
Evidence tier: Animal studies. Human observational data — circulating Humanin declines with age and correlates with CVD and Alzheimer's risk.
| Molecular weight | 2887.5 Da |
| Molecular formula | C121H212N38O34S |
| CAS number | 326916-19-2 |
| Half-life | Unknown |
| Administration | subcutaneous, intramuscular |
| Research dose | No established human dose. Animal studies use µg/kg ranges. |
Amino Acid Sequence
MAPRGFSCLLLLTSEIDLPVKRRA
Primary Mechanism
Cytoprotection via FPRL1/CXCR4 receptors, mitochondrial membrane stabilisation, anti-apoptotic signalling
Studied For
Alzheimer's disease (animal)cardiovascular protectioninsulin resistancecytoprotectionlongevity
Reconstitution
Reconstitute with bacteriostatic water.
Storage
Lyophilised: store at -20°C. Reconstituted: refrigerate, use within 30 days.
Notes
Mitochondrially encoded peptide, like MOTS-c. Plasma levels track strongly with health and longevity markers in human observational studies. Cohen lab (USC) — same group as MOTS-c.
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