Longevity
Epithalon
Epithalamin Tetrapeptide (Ala-Glu-Asp-Gly)
Evidence tier: Animal studies (lifespan extension). Some human observational data (telomere length, mortality in elderly). Russian Khavinson Institute research.
| Molecular weight | 390.35 Da |
| Molecular formula | C14H22N4O10 |
| CAS number | 307297-39-8 |
| Half-life | Unknown |
| Administration | subcutaneous, intramuscular, intranasal |
| Research dose | 5–10 mg/day for 10–20 day cycles, 2x per year |
Amino Acid Sequence
Ala-Glu-Asp-Gly
Primary Mechanism
Telomerase activation, melatonin regulation via pineal gland, antioxidant activity
Studied For
telomere elongationlifespan extensionsleep qualitycancer prevention (animal)immune function
Reconstitution
Reconstitute with bacteriostatic water. For a 10 mg vial add 2 mL BW for a 5,000 µg/mL solution.
Storage
Lyophilised: store at -20°C. Reconstituted: refrigerate at 2–8°C, use within 30 days.
Notes
Synthesised by Vladimir Khavinson. Tetrapeptide derived from the pineal gland. Long-term human studies from St. Petersburg Institute of Bioregulation show reduced mortality in elderly cohorts.
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